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Autophagy

Dysfunctional autophagy has been observed in ageing tissues and several ageing-associated diseases. Lifespan of model organisms such as yeast, worms, flies, and mice can be extended through promoting autophagy, either by genetic manipulations such as over-expression of Sirtuin 1, or by administrations of rapamycin, resveratrol or spermidine.

Papers

Autophagy in ageing and ageing-associated diseases

2013 - Li-qiang He. Lifespans of yeast, worms, flies, and mice can be extended through promoting autophagy, either by genetic manipulations such as over-expression of Sirtuin 1, or by administrations of rapamycin, resveratrol or spermidine. This review outlines recent developments in the genetic and pharmacological manipulations of autophagy that affects the lifespan.