top of page

Best results

pathway

pathway

1.

Unknown pathway

Autophagy

Dysfunctional autophagy has been observed in ageing tissues and several ageing-associated diseases. Lifespan of model organisms such as yeast, worms, flies, and mice can be extended through promoting autophagy, either by genetic manipulations such as over-expression of Sirtuin 1, or by administrations of rapamycin, resveratrol or spermidine.

Papers

Autophagy in ageing and ageing-associated diseases

2013 - Li-qiang He. Lifespans of yeast, worms, flies, and mice can be extended through promoting autophagy, either by genetic manipulations such as over-expression of Sirtuin 1, or by administrations of rapamycin, resveratrol or spermidine. This review outlines recent developments in the genetic and pharmacological manipulations of autophagy that affects the lifespan.

bottom of page